The robotic Bounty Hunter Freelance Peace-Keeping Agent first appeared as an adversary to the Transformers. Surviving that encounter he went on to have a run-in with none other than The Doctor from Doctor Who.

Wiki - Death's Head

A comedy parody of Spider-Man. There have been various versions of Spider-Ham including an episode of Ultimate Spider-Man animated series where Loki turns Spider-Man into Spider-Ham.

Wiki - Spider-Ham

Not to be confised with...

There have several incarnations of Deathlok. The first Deathlok was Luther Manning. He was an American soldier who, after his death, is reanimated with cyborg technology in the post-apocalyptic future of 1990 where he ends up battling his evil creator.

Wiki - Deathlok

Once a thief who even tried to sell the Earth and all it's population. She is a musician and a mutant with the power of teleportation. She has been associated with the New Mutants, X-Men, X-Force and Gladiators.

Wiki - Lila_Cheney

052 Lockjaw and Hairball (Chaos War), 033 Throg (The Mighty Thor), 080 Lockheed (Wolverine and the X-Men), WKM-013 Ms. Lion (Spider-Man and his Amazing Friends Team Base)


Throg - Following an encounter with Thor (in frog form) he gains a piece of Mjnoir and creates his own hammer.
Lockheed - an alien Dragon and long time companion of Kitty Pride of the X-Men.
Redwing - pet falcon of Falcon of the Avengers.
Zabu - Sabre-tooth tiger companion of Ka-Zar of the Savage Lands.
Hairball - originally a cat called Niels who gain powers the same as Speedball who became his owner.
Ms. Lion - pet dog of Spider-Mand and his Amazing Friends.

Wiki - Lockjaw and the Pet Avengers
 

Lester Verde, a bullied child, and highly intelligent scientist is the villain Doctor Bong!  He has no super-powers but used advanced technology as his weapons. Doctor Bong has been an adversary to Howard the Duck, She-Hulk, Deadpool and the Secret Avengers.

Wiki - Doctor Bong

One of the guardians of the Mindscape, a world within dreams, Sleepwalker was tricked into entering the mind of film student Rick Sheriden where he became trapped.  Only when Rick Rick sleeps can Sleepwalker manifest into reality to battle crime.

Wiki - Sleepwalker

A foe of Spider-Man and rival to Kingpin. Silvermane, Silvio Manfredi, is a career criminal with connections to the Maggia and Hydra.

Wiki - Silvermane
 

Spider-Man and Iceman, plus an original character, Firestar. As a trio called the Spider-Friends, they fought against various villains of the Marvel Universe.

Wiki - Spider-Man and His Amazing Friends

In Las Vegas, the demonic son of Mephisto, Blackheart opened a portal to bring Hell to Earth and overthrow his father, but only managed to bring a part of it. Venom was a fugitive there, with Red Hulk wanting to bring him to the authorities. X-23 was there looking for who stole a sample of her blood. And the new Ghost Rider detected Blackheart's malevolence.
Accidentally, the four heroes found themselves about to battle Blackheart.

During the battle, Red Hulk and Venom were thrown away by Blackheart. Flash gave the symbiote to Red Hulk and it bonded with him as well as the Spirit, thus becoming the new Ghost Rider.


Wiki - Circle_of_Four

Negasonic Teenage Warhead appears in the 2016 Deadpool film where her look and powers have changed. She is now a goth teen with new powers, she possesses the ability to bodily generate thermo-chemical energy and release it from her skin (much like Cannonball).

Originally Ellie Phimister was a Genoshan teenager, with pale skin and dark hair, who dressed as a goth and was a student of Emma Frost's telepathy class. During a tutoring session, Ellie reported having a recurring nightmare fifty times the previous night wherein all people in Genosha were exterminated.
Her powers are mainly precognition and minor telepathy.

https://en.wikipedia.org/wiki/Negasonic_Teenage_Warhead